Lawrence Sinoway, M.D., director, Penn State Hershey Heart and Vascular Institute, has been the lead investigator on “Acute and Chronic Afferent Engagement: Sympathetic and End Organ Responses,” a National Institutes of Health-funded project that started in 2010 and examines four separate aspects of peripheral arterial disease (PAD).
Less than 50 percent of PAD patients report the classic symptom of claudication, making the condition difficult to diagnose and treat. However, PAD is an alarming prognostic sign and correlates with significantly increased risk of cardiovascular mortality.¹ Sinoway describes another common therapeutic conundrum: “On the one hand, we as physicians see a disease caused by an arterial blockage and believe that by removing the blockage, patients will improve. While this may be true acutely, it is crucial to note that PAD, and indeed all forms of atherosclerosis, are chronic conditions that will return if patients don’t make lifestyle changes to reduce their future risk.”
In his primary study, Sinoway demonstrates that when PAD patients perform exercise with the affected leg, their arterial blood pressure becomes elevated as a result of the exercise pressor reflex, a cardiovascular change caused by muscular contractions. (Figure)
This blood pressure increase, which is directly related to the severity of the arterial blockage, can be controlled with high doses of ascorbic acid administered intravenously. Continue reading